Networks in Multiple Sclerosis

The interconnections between cells and systems is increasingly recognized in multiple sclerosis which is a complex disease. The goal of this Forum is to provide an update on the current state of knowledge regarding cellular, molecular and social networks in MS.

+ Thursday, February 27, 2020

9:45 - 11:00am European Charcot Foundation Symposium
11:15am - 1:45pm NAIMS/IMSVISUAL Symposium
2:00 - 2:10pm Opening Address
Jeffrey A. Cohen, Cleveland Clinic
Tanuja Chitnis, Brigham and Women's Hospital, Harvard University
Alexandre Prat, Université de Montréal
2:10 - 3:20pm Kenneth P. Johnson Memorial Lecture
Peter Calabresi, Johns Hopkins University
3:20 - 3:50pm BREAK
3:50 - 5:10pm SESSION 1 - Emerging Concepts in MS
Chairs: Fiona Costello, University of Calgary
Myla Goldman, University of Virginia
Adil Harroud, McGill University

Theme: Highlighting cutting edge studies that inform our understanding of the pathogenic mechanisms in MS, introduce novel measures to capture disease activity and advance treatment options for affected individuals. This session will be comprised of platform presentations by Young Investigators selected from submitted abstracts.
3:50 - 4:00pm Young Investigator Platform Presentation 1
4:00 - 4:10pm Young Investigator Platform Presentation 2
4:10 - 4:20pm Young Investigator Platform Presentation 3
4:20 - 4:30pm Young Investigator Platform Presentation 4
4:30 - 4:40pm Young Investigator Platform Presentation 5
4:40 - 4:50pm Young Investigator Platform Presentation 6
4:50 - 5:00pm Young Investigator Platform Presentation 7
5:00 - 5:10pm Young Investigator Platform Presentation 8
5:15 - 6:00pm National Multiple Sclerosis Society (NMSS) Barancik Award Presentation and Talk
6:00 - 8:00pm Poster Session 1 / Opening Networking Event

+ Friday, February 28, 2020

7:00 - 8:15am Industry Supported CME Satellite Symposium*
8:00 - 8:30am Breakfast
8:30 - 10:55am SESSION 2 - Network Analysis Applied to MS
Chairs: Philip De Jager, Columbia University
Nathalie Arbour, Université de Montréal
Brooke Rhead, University of California, Berkeley
8:30 - 8:35am Session Introduction
8:35 - 9:00am Network Theory as it Applies to MS
Sergio Baranzini, University of California, San Francisco
9:00 - 9:25am Applied Epigenomics for Understanding MS Pathogenesis
Maja Jagodic, Karolinska Institutet
9:25 - 9:55am BREAK
9:55 - 10:20am Data-mining for Predicting Therapeutic Response in MS
Bibi Bielekova, National Institutes of Health
10:20 - 10:45am Social Networks in MS and Related Diseases
Amar Dhand, Brigham and Women's Hospital
10:45 - 11:00am Panel Discussion
11:00am - 1:00pm Poster Session 2 / Lunch
1:00 - 3:45pm SESSION 3 - Immune Cell Networks in MS
Chairs: Benjamin M. Segal, Ohio State University
Gregory Wu, Washington University at St. Louis
Anne-Katrin Pröbstel, University of California, San Francisco
1:00 - 1:05pm Session Introduction
1:05 - 1:30pm Lymphocyte-myeloid Cell Networks in MS
Estelle Bettelli, University of Washington
1:30 - 1:55pm Imaging of the Immune Cell-endothelial Cell Network During CNS Repair
Dorian McGavern, National Institutes of Health, National Institute of Neurological Disorders and Stroke
1:55 - 2:25pm BREAK
2:25 - 2:50pm Lymphocyte-meningeal Mediated CNS Inflammation in MS
Zsuzsanna Fabry, University of Wisconsin-Madison
2:50 - 3:15pm Review of the Impact of Current Therapeutics on Immune Cell Networks
Fraunke Zipp, Universitätsmedizin Mainz
3:15 - 3:30pm Panel Discussion
3:30 - 3:45pm BREAK
3:45 - 5:15pm Cutting Edge Developments
Chairs: Tiffany Braley, University of Michigan
Susan Gauthier, Cornell University
Manu Rangachari, University of Laval
3:45 - 4:00pm Microbiome and Immune Analysis in AQP4 NMO
Scott Zamvil, University of California, San Francisco
4:00 - 4:15pm Epigenetic Changes in the Brain and Immune Cells of MS Patients
Patrizia Casaccia, CUNY
4:15 - 5:15pm Groundbreaking Abstracts
4:15 - 4:25pm Groundbreaking Presentation 1
4:25 - 4:35pm Groundbreaking Presentation 2
4:35 - 4:45pm Groundbreaking Presentation 3
4:45 - 4:55pm Groundbreaking Presentation 4
4:55 - 5:05pm Groundbreaking Presentation 5
5:05 - 5:15pm Groundbreaking Presentation 6
5:15 - 5:30pm Awards Presentation
5:30 - 6:30pm Awards Reception
6:45 - 8:00pm Industry Supported CME Satellite Dinner Symposium*
Update on the Pathogenesis, Diagnosis, and Treatment of Neuromyelitis Optica Spectrum Disorder This CME activity is provided by Med Learning Group. This independent Industry Supported Satellite Symposium is supported by an educational grant from Genentech.
8:00 - 10:00pm Conversations, Cocktails & Crepes
Grandview Public Market Networking Event
Keep the conversations going, enjoy a locally crafted cocktail and experience custom made crepes at this one of a kind ACTRIMS networking event! Located in the Warehouse District, this communal market is a collection of open-space eateries in a restored warehouse with an artisan, local feel and different eclectic food concepts. Guests may enjoy dinner first on their own with a 10% discount to an eatery option of their choosing, then join ACTRIMS for networking over cocktails and dessert crepes in two private event space locations within the warehouse. Space is limited.
COST: $20.00 includes cocktails and dessert.

+ Saturday, February 29, 2020

6:30 - 7:45am Industry Supported CME Satellite Symposium*
7:00 - 8:00am Breakfast
8:00 - 9:55am SESSION 4 - CNS Cellular Networks in MS
Chairs: V. Wee Yong, University of Calgary
Catherine Larochelle, Université de Montréal
Kirsten Scarlett Evonuk, Cleveland Clinic
8:00 - 8:05am Session Introduction
8:05 - 8:30am Microglia-cytokine Axis to Modulate Synaptic Connectivity: Potential Applications to MS
Dorothy Schafer, University of Massachusetts
8:30 - 8:55am Neuronal and Glial Cell Imaging in MS
Tarun Sighal, Brigham and Women's Hospital
8:55 - 9:20am Glial Cell-neuron Communication and Influence
Martin Kerchensteiner, Ludwig Maximilian University of Munich
9:20 - 9:45am Glial Cell Related Therapeutics
9:45 - 10:00am Panel Discussion
10:00 - 10:15am BREAK
10:15am - 12:10pm SESSION 5 - Neural-anatomical Networks
Chairs: Danny Reich, National Institutes of Health,
National Institute of Neurological Disorders and Stroke
Maria Rocca, Scientific Institute Ospedale San Raffaele
Christina Azevedo, University of Southern California
10:15 - 10:20am Session Introduction
10:20 - 10:45am Neuronal Hubs in MS
Eric Klawiter, Harvard University
10:45 - 11:10am fMRI Correlates of Cognitive Dysfunction in MS
Nancy Sicotte, Cedars Sinai Medical Center
11:10 - 11:35am Imaging Biomarkers of Remyelination and Repair
Jiwon Oh, University of Toronto
11:35am - 12:00pm Imaging of Neural Plasticity in MS
Peter Stys, University of Calgary
12:00 - 12:15pm Panel Discussion
12:15 - 1:35pm Lunch
12:20 - 1:35pm Industry Supported CME Satellite Symposium*
1:45 - 3:50pm SESSION 6 - Microbial Networks and Interactions with the CNS
Chairs: Emmanuelle Waubant, University of California, San Francisco
Stephanie Tankou, Mount Sinai
Marc Charabati, Université de Montréal
1:45 - 1:50pm Session Introduction
1:50 - 2:15pm The Gut Microbiota and MS with a Focus on Pediatric MS
Helen Tremlett, University of British Columbia
2:15 - 2:40pm Microbiota and Immune System Networks in the Periphery
Jennifer Gommerman, University of Toronto
2:40 - 3:05pm Potential for Microbiome as a Therapeutic Target
Howard Weiner, Harvard University
3:05 - 3:30pm Caloric Restriction and Dietary Interventions in MS
Ellen Mowry, Johns Hopkins University
3:30 - 3:45pm Panel Discussion
3:45 - 3:55pm Closing Remarks
Jeffrey A. Cohen, Cleveland Clinic
4:00 - 5:15pm Industry Supported CME Satellite Symposium*

*Independent Industry Supported CME Satellite Symposia are not included in the ACTRIMS Forum 2020 accredited program.

**Independent Industry Supported non-CME Product Theaters are not included in the ACTRIMS Forum 2020 accredited program.