Program Schedule
All times are listed in Pacific Time (PT). This schedule is subject to change.
+ Wednesday, February 22, 2023
| 12:00 - 7:30 pm | Resident Summit Program (Accepted Applicants Only) |
+ Thursday, February 23, 2023
| 8:00 - 9:00 am | Breakfast |
| 8:00 - 9:00 am | SS1. Industry Supported Satellite Symposium 1 Harnessing the Latest Advances to Preserve and Improve Cognitive Function in MS This CE activity is provided by PRIME Education, LLC. This independent Industry Supported Satellite Symposium is supported by an educational grant from Bristol Myers Squibb. |
| 9:00 - 9:15 am | Coffee Break |
| 9:15 - 10:45 am | ACTRIMS Differential Diagnosis of Suspected Multiple Sclerosis, An Update | |
| 9:15 - 9:25 am | Introduction - The International MS Differential Diagnosis Consortium Andrew Solomon, University of Vermont |
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| 9:25 - 9:50 am | MS Differential Diagnosis: Updated Approaches and Red Flags Eoin Flanagan, Mayo Clinic |
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| 9:50 - 10:15 am | MS Differential Diagnosis: Considerations in Global Populations Jorge Correale, Raúl Carrea Institute for Neurological Research |
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| 10:15 - 10:40 am | MS Differential Diagnosis: Considerations in Underrepresented Populations Lilyana Amezcua, University of Southern California |
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| 10:45 - 11:00 am | Coffee Break |
| 11:00 am - 12:00 pm | AP1. NAIMS Symposium - MS MRI Goes Viral Too Chairs: Jiwon Oh, University of Toronto and Daniel Reich, National Institutes of Health, National Institute of Neurological Disorders and Stroke | |
| 11:00 - 11:04 am | Introduction Jiwon Oh, University of Toronto and Daniel Reich, National Institutes of Health, National Institute of Neurological Disorders and Stroke |
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| 11:04 - 11:27 am | Viral Intelligence: Sharing Knowledge and Accelerating Experimentation through a Collaborative Platform Charles Guttmann, Brigham and Women’s Hospital |
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| 11:27 - 11:50 am | An Overview of MRI Gene Expression Strategies Alan Koretsky, National Institutes of Health, National Institute of Neurological Disorders and Stroke |
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| 11:50 am - 12:00 pm | Radiological Characterization of Cortical Lesions in Progressive Multifocal Leukoencephalopathy Sarita Walvekar, National Institutes of Health, National Institute of Neurological Disorders and Stroke |
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| 12:00 - 1:30 pm | Lunch in the Industry Hub |
| 12:15 - 1:15 pm | SS2. Industry Supported Satellite Symposium 2
Battle of the Biomarkers: Assessing Key Factors in Prognosis, Monitoring, and Therapeutic Decision-Making for Disease Worsening in Multiple Sclerosis This CE activity is jointly provided by Purdue College of Pharmacy Office of Continuing Education and EfficientCME. This independent Satellite Symposium is supported by an educational grant from Novartis Pharmaceuticals Corporation. |
| 12:15 - 12:45 pm | BE1. Brain Exchange Community Discussion 1: MS Prodrome |
| 12:45 - 1:15 pm | BE2. Brain Exchange Community Discussion 2: MS in Underrepresented Populations |
| 1:30 - 2:30 pm | Welcome & Kenneth P. Johnson Memorial Lecture
Lawrence Steinman, Stanford University |
| 2:30 - 2:40 pm | Coffee Break |
| 2:40 - 4:15 pm | S1. Session 1 - Emerging Concepts in MS Theme: Highlighting studies that inform our understanding of the pathogenic mechanisms in MS, introduce novel measures to capture disease activity and advance treatment options for affected individuals. This session will be comprised of platform presentations by Young Investigators selected from submitted abstracts. Chairs: Haritha Desu, Université de Montréal and Benjamin Segal, The Ohio State University |
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| 2:40 - 2:45 pm | Introduction | ||
| 2:45 - 3:00 pm | S1.1: A Multi Modular Approach to Characterize Multiple Sclerosis Brain Pathology in Rapid Autopsy Brain Tissue Stephanie Zandee, Université de Montréal | ||
| 3:00 - 3:15 pm | S1.2: Genetic Analysis of CNS Autoimmunity Using the Diversity of the Collaborative Cross Reveals Unique Phenotypes and Mechanisms Emily Holt, University of Vermont | ||
| 3:15 - 3:30 pm | S1.3: Psychiatric Morbidity in Multiple Sclerosis During the Prodromal Period Anibal Chertcoff, University of British Columbia |
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| 3:30 - 3:45 pm | S1.4: Retinal Synaptic Loss Occurs During Neuroinflammation and is Mediated by Lymphocyte-Microglial-Astrocyte Activity Thomas Garton, Johns Hopkins University |
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| 3:45 - 4:00 pm | S1.5: Identification of Pathogenic Gut Bacteria Underlying Multiple Sclerosis Progression Daiki Takewaki, National Center of Neurology and Psychiatry |
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| 4:00 - 4:15 pm | S1.6: Myelin Abnormalities in the Cervical Spine Cord is Associated with Clinical Disability Across MS Subtypes Lisa Eunyoung Lee, University of Toronto |
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| 4:15 - 4:25 pm | Coffee Break |
| 4:25 - 5:30 pm | CE1. Cutting Edge Developments 1 Theme: Cutting-edge platform presentations selected from submitted abstracts. Each presenter will have 15 minutes total for their presentation - 12 minutes for the presentation and 3 minutes for Q&A. Chairs: Anne Cross, Washington University in St. Louis and Deepak Kaushik, Memorial University of Newfoundland |
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| 4:25 - 4:30 pm | Introduction | |
| 4:30 - 4:45 pm | CE1.1: Proteogenomic Immune Signatures Delineate the Landscape of Pediatric Acquired Demyelinating Syndromes Diego Espinoza, University of Pennsylvania |
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| 4:45 - 5:00 pm | CE1.2: A Comparative Effectiveness Trial of Telephone-Delivered Cognitive Behavioral Therapy, Modafinil, and Combination Therapy of Both Interventions for Fatigue in Multiple Sclerosis: Primary Results From the COMBO-MS Trial Tiffany Braley, University of Michigan |
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| 5:00 - 5:15 pm | CE1.3: T-bet+ Memory B Cells Induce Disease Relapses in Experimental Autoimmune Encephalomyelitis Rajiv Jain, University of Calgary |
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| 5:15 - 5:30 pm | CE1.4: Sensitivity of Portable Ultra Low Field Magnetic Resonance Imaging for Radiological Diagnosis of Multiple Sclerosis Serhat Okar, National Institutes of Neurological Disorders and Stroke, National Institutes of Health |
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| 5:30 - 6:30 pm | Happy Hour in the Industry Hub |
| 5:35 - 5:55 pm | IS1. Industry Showcase 1 How Diversity, Equity & Inclusion Neurodisparity Fellowships Drive Innovation in MS Patient Care This activity is an independently supported presentation provided by EMD Serono, Inc. |
| 6:05 - 6:25 pm | IS2. Industry Showcase 2 N-MOmentum: The Largest Prospective, Placebo-controlled Clinical Trial in NMOSD, Designed for Robust Attack Assessment This activity is an independently supported presentation provided by Horizon Therapeutics. |
| 6:30 - 7:30 pm | Poster Session 1 Even-numbered posters present from 6:30-7:00 pm; Odd-numbered posters present from 7:00-7:30pm |
| 7:30 - 8:30 pm | "MS in Black and African Americans” Documentary Premiere & Panel Discussion This activity is an independently supported presentation supported by Biogen and is not included in the ACTRIMS Forum 2023 accredited program. No CE credit provided. |
| 7:45 - 8:45 pm | iWiMS Event All are welcome to join iWiMS for a review of the past year’s activities and to discuss what’s next for the mentorship program, interest groups, partnerships and more! |
+ Friday, February 24, 2023
| 7:00 - 8:00 am | Forum Wellness Walk Meet at the Marina Terrace for a casual group walk before programming begins! The path is ~0.75 miles - walk it once or multiple times! |
| 7:30 - 9:00 am | Breakfast |
| 7:30 - 7:50 am | IS3. Industry Showcase 3 Improving Comprehensive MS Care This activity is an independently supported presentation provided by BJC Medical Group. |
| 8:00 - 9:00 am | SS3. Industry Supported Satellite Symposium 3
BTK Inhibition as an MS Treatment Modality: Where Do We Stand and Where Are We Headed? This CE activity is provided by PVI, PeerView Institute for Medical Education. This independent Industry Supported Satellite Symposium is supported by an educational grant from Sanofi. |
| 9:10 - 10:45 am | S2. Session 2 - Viral Triggers of MS Theme: Epidemiology, mechanisms and therapeutic interventions for viral infections as triggers for MS. Chairs: Daniel Ontaneda, Cleveland Clinic and E. Ann Yeh, University of Toronto |
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| 9:10 - 9:15 am | Introduction | |
| 9:15 - 9:30 am | S2.1: Viral Triggers of MS: Historical Overview Steven Jacobson, National Institutes of Health |
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| 9:30 - 9:45 am | S2.2: EBV Epidemiology in Different Populations Marianna Cortese, Harvard T. H. Chan School of Public Health |
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| 9:45 - 10:00 am | S2.3: Epstein-Barr Virus Infection of B Cells Promotes Th1-mediated Disease in Multiple Sclerosis Jessica Allanach, The University of British Columbia |
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| 10:00 - 10:30 am | S2.4: Debate: How To and Should We Target EBV in MS? Peter Calabresi, Johns Hopkins University and Jeffrey I. Cohen, National Institutes of Health |
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| 10:30 - 10:45 am | Q&A Discussion | |
| 10:45 - 10:55 am | Coffee Break |
| 10:55 am - 12:00 pm | CE2. Cutting Edge Developments 2 Theme: Cutting-edge platform presentations selected from submitted abstracts. Each presenter will have 15 minutes total for their presentation - 12 minutes for the presentation and 3 minutes for Q&A. Chairs: Alise Carlson, Cleveland Clinic and Hedwich Kuipers, University of Calgary |
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| 10:55 - 11:00 am | Introduction | |
| 11:00 - 11:15 am | CE2.1: Role of Astroglial TNFR2 Signaling in Synaptic and Cognitive Function in Multiple Sclerosis Brianna Carney, University of Miami |
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| 11:15 - 11:30 am | CE2.2: Randomized Clinical Trial of Intermittent Calorie Restriction in People with Multiple Sclerosis Laura Piccio, Washington University in St. Louis |
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| 11:30 - 11:45 am | CE2.3: A Mutation in the Nr1h3 Regulator of Reverse Cholesterol Transport Underlies Primary Progressive Pathophysiology in a Preclinical Model Based on Familial MS Emily Kamma, University of British Columbia |
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| 11:45 am - 12:00 pm | CE2.4: Molecular Mechanisms Associated with Multiple Sclerosis Progression, Severity and Phenotype Peter Kosa, National Institute of Allergy and Infectious Diseases |
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| 12:00 - 1:30 pm | Lunch in the Industry Hub |
| 12:15 - 1:15 pm | SS4. Industry Supported Satellite Symposium 4
A Deeper Look at Neuromyelitis Optica Spectrum Disorder: A Glimpse Onto the Clinic Floor with Specialists This CE activity is jointly provided by Purdue College of Pharmacy Office of Continuing Education and EfficientCME. This independent Satellite Symposium is supported by an educational grant from Genentech, a Member of the Roche Group. |
| 12:15 - 12:45 pm | BE3. Brain Exchange Community Discussion 3: Pitfalls and Opportunities in Observational Research |
| 12:45 - 1:15 pm | BE4. Brain Exchange Community Discussion 4: Targeting Chronic Active Inflammation |
| 1:30 - 3:00 pm | S3. Session 3 - Impact of COVID-19 and Other Pathogens on MS
Theme: Understanding how infectious agents induce demyelination and alter the disease course in MS. Chairs: Raphael Schneider, UnityHealth Toronto and Michael Wilson, University of California, San Francisco |
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| 1:30 - 1:35 pm | Introduction | |
| 1:35 - 1:50 pm | S3.1: What Types of Infection Are Implicated in MS Pathogenesis? Scott Montgomery, Örebro University |
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| 1:50 - 2:05 pm | S3.2: HIV and MS Elaine Kingwell, University College London |
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| 2:05 - 2:20 pm | S3.3: Insights from Viral-Induced Demyelination Animal Models in MS Stanley Perlman, University of Iowa |
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| 2:20 - 2:35 pm | S3.4: Exacerbation of MS, Other Demyelinating Events and Outcomes in Relation to COVID-19 Yang Mao-Draayer, University of Michigan |
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| 2:35 - 3:00 pm | Q&A Discussion | |
| 3:00 - 3:10 pm | Coffee Break |
| 3:10 - 4:40 pm | S4. Session 4 - Going Viral: Trends in MS Research Theme: Review of hot topics gone “viral” in MS research: chronic active lesions, transcriptomics, digital tools and diversity. Chairs: David Gosselin, Université Laval and María Inés Gaitán, National Institute of Neurological Disorders and Stroke, National Institutes of Health |
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| 3:10 - 3:15 pm | Introduction | |
| 3:15 - 3:30 pm | S4.1: Imaging Chronic Active Inflammation in MS Susan Gauthier, Weill Cornell Medical College |
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| 3:30 - 3:45 pm | S4.2: Role of sc, snRNAseq to Understand MS Sergio Baranzini, University of California, San Francisco |
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| 3:45 - 4:00 pm | S4.3: Next-Generation Digital Tools to Monitor MS Jennifer Graves, University of California, San Diego |
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| 4:00 - 4:15 pm | S4.4: Diversity and Inclusion in Clinical Research in MS Leorah Freeman, University of Texas at Austin |
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| 4:15 - 4:40 pm | Q&A Discussion | |
| 4:40 - 4:50 pm | Coffee Break |
| 4:50 - 5:50 pm | BP1. National MS Society Barancik Award Presentation and Talk |
| 5:50 - 6:30 pm | Happy Hour in the Industry Hub |
| 6:00 - 6:20 pm | IS4. Industry Showcase 4 Gain Actionable Insights of Patients’ Disease Activity Using the Only MS Multivariate Biomarker Test This activity is an independently supported presentation provided by Octave Bioscience. |
| 6:30 - 7:30 pm | Poster Session 2 Even-numbered posters present from 6:30-7:00 pm; Odd-numbered posters present from 7:00-7:30 pm |
| 7:45 - 8:45 pm | AP2. LACTRIMS Symposium - LACTRIMS Gone Viral Chairs: Victor M. Rivera, Baylor College of Medicine and Fernando Gracia LACTRIMS President, Hospital Santo Tomas, Universidad Interamericana de Panamá | |
| 7:45 - 7:50 pm | Introduction | |
| 7:50 - 8:05 pm | Viral Triggers for MS in Latin-America Jorge Correale, Raúl Carrea Institute for Neurological Research |
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| 8:05 - 8:20 pm | Infectious Mimickers of MS Lorna Galleguillos, Clínica Alemana, Universidad de Chile |
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| 8:20 - 8:35 pm | Mis Diagnosis of MS in LATAM María Gaitán, National Institutes of Neurological Disorders and Stroke |
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| 8:35 - 8:45 pm | Q&A Discussion | |
+ Saturday, February 25, 2023
| 7:30 - 8:30 am | Breakfast |
| 7:30 - 8:30 am | AP3. European Charcot Foundation Symposium - Do We Still Need an Attack to Diagnose Multiple Sclerosis? Chairs: Gilles Edan, University Hospital Rennes and Mark Freedman, University of Ottawa | |
| 7:30 - 7:35 am | Introduction | |
| 7:35 - 7:50 am | Epidemiological Evidence Christine Lebrun-Frenay, University Nice |
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| 7:50 - 8:05 am | Neurobiological Findings Hans Peter Hartung, Universität Düsseldorf |
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| 8:05 - 8:20 am | Diagnostic and Treatment Implications Xavier Montalban, Multiple Sclerosis Centre of Catalonia (Cemcat), Vall d'Hebron University Hospital |
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| 8:20 - 8:30 am | Q&A Discussion | |
| 8:30 - 8:45 am | Coffee Break |
| 8:45 - 9:00 am | Awards Presentation |
| 9:00 - 10:30 am | S5. Session 5 - Viral Complications of DMTs Theme: Mitigating, treating and better understanding the risk of viral infections associated with disease modifying medications in MS. Chairs: Carlos Pardo-Villamizar, Johns Hopkins University and Eric Williamson, University of California, Los Angeles |
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| 9:00 - 9:05 am | Introduction | |
| 9:05 - 9:20 am | S5.1: Mitigating Risks of DMTs: Patient Selection, Vaccination and Biomarkers Dorlan Kimbrough, Duke University |
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| 9:20 - 9:35 am | S5.2: Mitigating Risks of DMTs: the Role of Imaging in Viral Infections Omar Al-Louzi, Cedars-Sinai |
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| 9:35 - 9:50 am | S5.3: PML: Pathophysiology and Treatment Irene Cortese, National Institutes of Health |
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| 9:50 - 10:05 am | S5.4: PML Risk: Insights From scRNAseq Studies Claire Riley, Columbia University |
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| 10:05 - 10:30 am | Q&A Discussion | |
| 10:30 - 10:40 am | Coffee Break |
| 10:40 am - 12:10 pm | S6. Session 6 - Going Viral: Inclusive and Accessible Innovations for MS Care Theme: Review of hot topics gone “viral” in MS research with a focus on lifestyle modification and improving access to care. Chairs: Marwa Kaisey, Cedars-Sinai and Julia O'Mahony, University of Manitoba |
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| 10:40 - 10:45 am | Introduction | |
| 10:45 - 11:00 am | S6.1: Diet in MS Ilana Katz Sand, Mount Sinai - New York |
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| 11:00 - 11:15 am | S6.2: Exercise in MS E. Ann Yeh, University of Toronto |
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| 11:15 - 11:30 am | S6.3: Use of AI and MRI for MS Care: How Does This Improve Care and Accessibility? Michael Dwyer, University at Buffalo |
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| 11:30 - 11:45 pm | S6.4: Social Determinants - Lessons Learned and How Do We Do Better? Lilyana Amezcua, University of Southern California |
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| 11:45 am - 12:10 pm | Q&A Discussion | |
| 12:10 - 12:30 pm | Boxed Lunch Available |
| 12:30 - 1:30 pm | AP4. IMSVISUAL Symposium | |
| 12:30 - 12:35 pm | Introduction Shiv Saidha, Johns Hopkins University |
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| 12:35 - 12:50 pm | In Vivo Retinal Imaging in Translational Research Frederike Oertel, University of California, San Francisco |
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| 12:50 - 1:00 pm | Quantifying Retrograde Trans-Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis Sargis Manukyan, Cedars Sinai |
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| 1:00 - 1:10 pm | Integration of MS Risk Genes with Single Cell Transcriptomics in the Retina and Predictors of Retinal Layer Thicknesses Samantha Hao, Johns Hopkins University |
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| 1:10 - 1:20 pm | Attractor-Like Changes in Dynamic Brain Connectivity Relate to Clinical Disability in Multiple Sclerosis Andrew Russo, Harvard, Massachusetts General Hospital |
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| 1:20 - 1:30 pm | The Effects of Myelin Loss, Repair, and Remyelination Therapies on Visual Cortical Function Gustavo Della Flora Nunes, University of Colorado |
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+ Virtual On-Demand Sessions
| Virtual | SS5. Industry Supported Satellite Symposium 5 Neuromyelitis Optica Spectrum Disorder: Optimizing Clinical Decision-Making in a Rapidly Evolving Therapeutic Landscape This CE activity is provided by Vindico Medical Education. This independent Industry Supported Satellite Symposium is supported by an educational grant from Horizon Therapeutics USA, Inc. |
| Virtual | IS5. Industry Showcase 5 A Changing Perspective on Drivers of Disability Accumulation: The Role of Neuroinflammation This activity is an independently supported presentation provided by Sanofi. |
| Virtual | IS6. Industry Showcase 6 Understanding Smoldering MS This activity is an independently supported presentation provided by Sanofi. |
Download Printable PDF Program.
*Independent Industry Supported Satellite Symposia and Industry Showcases are not included in the ACTRIMS Forum 2023 accredited program. No CE credit provided for Industry Showcases.
**Industry Hub will be open Thursday, February 23 from 8:00 am - 7:30 pm and Friday, February 24 from 7:30 am - 7:30 pm.